For consortium members

Prompt Engineering an Informational Chatbot for Education on Mental Health Using a Multiagent Approach for Enhanced Compliance With Prompt Instructions: Algorithm Development and Validation

Background:People with schizophrenia often present with cognitive impairments that may hinder their ability to learn about their condition. Education platforms powered by large language models (LLMs) have the potential to improve the accessibility of mental health information. However, the black-box nature of LLMs raises ethical and safety concerns regarding the controllability of chatbots. In particular, […]

Approximating the semantic space: word embedding techniques in psychiatric speech analysis

Large language models provide high-dimensional representations (embeddings) of word meaning, which allow quantifying changes in the geometry of the semantic space in mental disorders. A pattern of a more condensed (‘shrinking’) semantic space marked by an increase in mean semantic similarity between words has been recently documented in psychosis across several languages. We aimed to […]

A single composite index of semantic behavior tracks symptoms of psychosis over time

Semantic variables automatically extracted from spontaneous speech characterize anomalous semantic associations generated by groups with schizophrenia spectrum disorders (SSD). However, with the use of different language models and numerous aspects of semantic associations that could be tracked, the semantic space has become very high-dimensional, challenging both theoretical understanding and practical applications. This study aimed to […]

The ‘L-factor’: Language as a transdiagnostic dimension in psychopathology

Thoughts and moods constituting our mental life incessantly change. When the steady flow of this dynamics diverges in clinical directions, the possible pathways involved are captured through discrete diagnostic labels. Yet a single vulnerable neurocognitive system may be causally involved in psychopathological deviations transdiagnostically. We argue that language viewed as integrating cortical functions is the […]